Mayo Clinic Comprehensive Cancer Center is one of only 52 NCI-designated Comprehensive Cancer Centers in the United States — a recognition reserved for institutions with exceptional depth in cancer research, clinical trials, and multidisciplinary care. Located in the iconic Gonda Building at Mayo Clinic's Rochester campus, the cancer center represents the convergence of the world's most advanced oncology research with the extraordinary clinical expertise of Mayo's integrated specialist teams. The cancer center offers evaluation and treatment for every type of cancer, with particular national recognition in rare and complex malignancies that may be undiagnosed or undertreated elsewhere. Mayo's diagnostic capabilities — including advanced molecular pathology, next-generation sequencing of tumor DNA, liquid biopsy, and PET-MRI fusion imaging — provide a level of diagnostic precision unmatched at most institutions. Patients at the Mayo Clinic Cancer Center have access to the most comprehensive clinical trials portfolio in the nation across all phases — including first-in-human Phase I studies of novel agents not available anywhere else. CAR-T cell therapy, bispecific antibodies, radioligand therapy, and tumor-infiltrating lymphocyte (TIL) therapy are among the innovative treatments available. The cancer center's multidisciplinary tumor boards bring together subspecialists from medical oncology, surgical oncology, radiation oncology, radiology, pathology, and palliative care to develop personalized treatment recommendations.
